Local females

Added: Kelechi Cornell - Date: 12.12.2021 14:01 - Views: 45084 - Clicks: 9237

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It is now apparent that in men and in postmenopausal women, estrogens have important physiological and pathophysiological roles. However, importantly, these actions are at a local level, namely paracrine, autocrine, and even 'intracrine' rather than endocrine in the classical sense.

Thus for example local estrogen biosynthesis in the bones of men plays a hitherto unsuspected role in the maintenance of bone mineralization and in epiphyseal fusion; and in the testes, estrogen is essential for male germ cell development.

On the other hand, in postmenopausal women, the mesenchymal cells of the breast are the major source of estrogen responsible for breast cancer development. This realization points to the importance of circulating C19 precursors in the maintenance local females adequate estrogen biosynthesis in extragonadal sites and suggests the possibility of new therapies to block estrogen synthesis in a tissue-specific fashion.

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Similar articles Local females role of local estrogen biosynthesis in males and females. Simpson E, et al. Trends Endocrinol Metab. PMID: Review. Sources of estrogen and their importance. Simpson ER. J Steroid Biochem Mol Biol. Aromatase--a brief overview.

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Simpson ER, et al. Annu Rev Physiol. Aromatization of androgens in women: current concepts and findings. Fertil Steril. Minireview: aromatase and the regulation of estrogen biosynthesis--some new perspectives. See all similar articles. Yamamoto A, et al. Int J Mol Sci. Sex-specific effects of high-fat diet on cognitive impairment in a mouse model of VCID.

Salinero AE, et al. Epub Sep Ben-Batalla I, et al. Front Immunol. Protective effect of estrogen against calcification in the cartilage endplate. Sheng B, et al. Int J Clin Exp Pathol. Brocca ME, et al.

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Cell Mol Neurobiol. Epub Aug 6. See all "Cited by" articles. Publication types Research Support, Non-U. Gov't Actions. Research Support, U. Gov't, P. Review Actions. Animals Actions. Calcification, Physiologic Actions. Female Actions. Gene Expression Regulation Actions. Humans Actions.

Male Actions. Substances Estrogens Actions. Aromatase Actions. Related information MedGen. Full text links [x] Sheridan PubFactory. Copy Download.

Local females

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